Many factors can potentially interfere with the development of attachment between the mother or primary caregiver and the infant-curtailed mother/child interaction, including lack of holding, poor verbal and sensory stimulation and inadequate physical care and feeding. Alcohol and drug use by the caregiver may also affect parenting ability and interfere with the formation of an attachment relationship. Certain situations, such as lack of a primary caregiver, prolonged hospital stay, extreme poverty, parental inexperience, and parental social isolation, may predispose a child to developing in a deprived environment that in turn may lead to a Reactive Attachment Disorder. However, it must be noted that some children form stable attachments and social relationships despite marked neglect or abuse.